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Writer's pictureTonya N Tookey

Disease Progression: The 4 Stages of Rheumatoid Arthritis

The progression of rheumatoid arthritis can be understood in terms of its 4 stages and the characteristics of each stage. The 4 stages are


  • Stage 1: Disease Onset

  • Stage 2: Moderate Disease Activity

  • Stage 3: Severe Disease Activity

  • Stage 4: End-Stage Disease Activity


Let's further explore each stage to understand what symptoms are associated with each stage.



Autoimmune diseases are complex, and rheumatoid arthritis is no exception. Not everyone will test positive for antibodies or rheumatoid factor on blood tests, and not everyone will be symptomatic at the earliest onset of disease activity. Each person's disease activity is as unique as you and me. You know your body best, so listen to your body when it tells you something isn't quite right.


If you suspect you are experiencing early symptoms of rheumatoid arthritis, the Centers for Disease Control and Prevention recommends that you contact your primary care physician right away. Do not hesitate. Early diagnosis and early intervention and treatment are crucial to your overall prognosis.

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